Arunkumar R
India
Research Article
Impact of Quercetin, Diallyl Disulfide and Nimbolide on the Regulation of Nuclear Factor Kappa B Expression in Prostate and Breast Cancer Cell Lines
Author(s): Arunakaran J, Arunkumar R, Elumalai P and Senthilkumar KArunakaran J, Arunkumar R, Elumalai P and Senthilkumar K
NFκB is a key regulator of genes involved in cell activation and proliferation. Activation of NFκB has been implicated in prostate and breast cancer development and growth. Quercetin, a flavonoid from onion, diallyl disulfide (DADS) an organosulfur compound from garlic and nimbolide, a tetranortriterpenoid from neem leaf have been shown to anticancer activities in various cancers. All the above compounds decreased the prostate and breast cancer cell viability. The IC-50 value of PC-3 cells of Quercetin was 100 μM; DADS was 40 μM and IC-50 value of breast cancer cells such as MCF-7, MDA-MB-231 cells were 4 μM and 6 μM, respectively. Therefore, for further studies 50 and 100 μM quercetin, 20 and 40 μM DADS, were selected for prostate cancer treatment. 2 and 4 μM/ml nimbolide concentrations for MCF-7 cells and 4 and 6 μM/ml for MDA-MB-231 breast cancer.. View More»
