AK Bhalla
India
Research Article
Comparative Efficacy of Once Daily Insulin Glargine with Twice Daily NPH Insulin in Children with Type 1 Diabetes
Author(s): Arushi Saini, Devidayal, Savita Verma and AK BhallaArushi Saini, Devidayal, Savita Verma and AK Bhalla
Objective: To compare the efficacy of insulin glargine and insulin NPH in terms of glycemic control and risk of hypoglycemia in children with Type 1 diabetes (T1D) mellitus.
Design: Prospective, randomized, open label, controlled trial.
Setting: Pediatric Diabetes Clinic of a tertiary care hospital.
Subjects: Eighty T1D children between 2 to12 years diagnosed for at least six months.
Randomization: Computer generated random number table was used to randomize the patients into Glargine (n=40) and NPH (n=40) groups.
Intervention: Patients received either once daily insulin glargine or twice daily NPH insulin as basal insulin. Monthly follow up was done for 6 consecutive months.
Results: In the glargi.. View More»
