Abdullah Al Mamun
Bangladesh
Review Article
Autophagic Dysfunction in Type 2 Diabetes Mellitus: Pathophysiology and Therapeutic Implications
Author(s): Md. Tanjir Islam, Md. Sahab Uddin, Kamrun Nahar Lucky, Md. Manjurul Islam, Sheik Md. Saiful Islam, Md. Tanvir Kabir, Md. Farhad Hossain, Abdullah Al Mamun and Md. Shah AmranMd. Tanjir Islam, Md. Sahab Uddin, Kamrun Nahar Lucky, Md. Manjurul Islam, Sheik Md. Saiful Islam, Md. Tanvir Kabir, Md. Farhad Hossain, Abdullah Al Mamun and Md. Shah Amran
Autophagy is an intracellular catabolic system by which cells degrade and recycle cytoplasmic constituents such as organelles and proteins through the lysosome-dependent path. Belgian biochemist, Christian de Duve coined the name "autophagy" in 1963. The identification of autophagy-related genes and finally discoveries of mechanisms for autophagy led to the award of the 2016 Nobel Prize in Medicine or Physiology to Japanese cell biologist, Yoshinori Ohsumi specializing in autophagy. Autophagy shows a crucial role in removing aggregated proteins and damaged organelles in order to conserve intracellular homeostasis. In order to control cellular homeostasis and disease states autophagy illustrates a vital role. For insulin resistant patients, insulin secretion and the mass of pancreatic β-cells is increased on account of alterations in the expression and activities of nume.. View More»
