Journal of Diabetes & Metabolism

ISSN - 2155-6156

Obesity and Insulin Resistance

Obesity often leads to insulin resistance, where the body’s cells become less responsive to insulin. This resistance disrupts glucose uptake and regulation, causing elevated blood sugar levels. Adipose tissue, particularly visceral fat, releases inflammatory cytokines that interfere with insulin signaling. This chronic state of inflammation exacerbates metabolic dysfunction, increasing the risk of developing type 2 diabetes and cardiovascular diseases. Addressing obesity through lifestyle changes, such as diet and exercise, is crucial in improving insulin sensitivity and reducing associated health risks.

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