Hormonal regulation of metabolism involves hormones that control various metabolic processes, including glucose homeostasis, lipid metabolism, and protein synthesis. Key hormones include insulin, which promotes glucose uptake and storage; glucagon, which stimulates glucose release; thyroid hormones, which regulate overall metabolic rate; and cortisol, which affects glucose metabolism and fat storage. These hormones work together to maintain energy balance, adapt to fasting or feeding states, and support growth and repair. Disruptions in hormonal regulation can lead to metabolic disorders such as diabetes, thyroid dysfunction, and obesity.