Ashlesha P Pandit, Waychal Pooja D, Kavita Kumari and Minal Chopda
Accepted Abstracts: Nat Prod Chem Res
Natural polysaccharides have been widely used because of their biocompatibility and biodegradabilityproperties. An attempt has been made to explore tamarind seed xyloglucan (TSX), a glucosaminoglycan polysaccharide extracted from the kernels of seeds of Tamarindus indica Linn., family Fabaceae for bimodal(immediate and controlled)drug release of multilayer tablet. Chemically TSX powder is highly branched carbohydrate polymer. High drug holding capacity of this polysaccharide was investigated for bimodal release.An in-house extracted TSX polysaccharide was characterized for swelling index, flow property, viscosity and compatibility with drug. Multilayer tablet was comprised of immediate release layer of tramadol hydrochloride (an analgesic agent), followed by tri-layer. This tri-layer consisted of upper and lower barrier layers of TSX and middle layer of drug granular matrix. Multilayer tablets were compressed based on 32 factorial design consideringconcentrations of matrix and barrier TSX layers as independent variables. Immediate release layer released the drug within 90 min in acidic media, revealing the retarded action showed bypolysaccharide layer attached to this layer. Granules of matrix layer were prepared by wet granulation technology.Multiplayer tablet of TSX was evaluated for hardness, thickness and drug content. Dissolution test in presence of rat caecal content was found to control the drug release rate for more than 9h. Stability studies confirmed the stable formulation. Thus, this study suggested that inexpensiveand abundantly available natural TSX can act as a potential polymer for bimodal releaseof a multilayer tablet.
Ashlesha P Pandit has completed PhD from RTM Nagpur University. She is the Associate Professor (Pharmaceutics) ofJSPM Rajarshi Shahu College of Pharmacy & Research, Pune, India, affiliated to University of Pune. She has 13 years of teaching and research experience.She has more than 8publications and 1 patent to her credit. She is serving as referee and guest editor for repute journals. Her areas of research interest areexploration and application of natural polymers in various drug delivery systems, solubility enhancement of poorly-water soluble drugs and formulation development of multi-particulate, enteric coated and medicated chewing gum asdrug delivery system.
