Mehtap Kacar
Yeditepe University, Turkey
Posters & Accepted Abstracts: J Diabetes Metab
Diabetes is associated with increased risk for atherosclerosis which is a chronic inflammatory disease. The increased inflammation and accelerated atherosclerosis are observed in diabetic patients and the inflammatory response in the pathogenesis of atherosclerosis is generated by interactions between plasma lipoproteins, monocytes/macrophages, T lymphocytes, endothelial cells, smooth muscle cells and the extracellular matrix of the arteries. Macrophages are the most important cells in pathogenesis of atherosclerosis, and play an important role in the generation of foam cells which produce inflammatory mediators. M1 and M2 macrophages are present in the atherosclerotic plaques where M1 macrophages play an important role in the development of plaque; on the other hand M2 macrophages help in the regression of inflammation. Hence, hyperglycemia and advanced glycation end products (AGEs) effect macrophages polarization.
Email: mehtapkacar69@gmail.com
