Musikhina Natalia
Tyumen Cardiology Center, Russian Federation
Posters & Accepted Abstracts: J Diabetes Metab
Purpose: To perform. prospective comparative analysis of lipid profiles and markers of inflammation and endothelial dysfunction in groups of CAD patients with and without DM. Methods: 116 patients aged 62.5±6.7 years with CAD and stable angina were divided into two groups:. group included patients with CAD (n=63) and II group. CAD patients with type. DM (n=53). Selective coronary angiography showed signs of significant coronary stenosis in all patients (>75%). All angioplasty patients was conducted. Results: Serum laboratory tests were performed during the course of standard therapy at baseline and in 12±2.4 months of observation. At baseline, patients of II group had significantly increased atherogenic indices of the lipid profile (total cholesterol, LDL, apolipoprotein B) and flammation markers (high-sensitivity C-reactive protein, homocysteine, interleukin-1β) compared to. group. Group. had higher levels of soluble CD40 ligand (CD40L). In II group patients with CAD and DM had more numerous and highly significant interrelations between atherogenic lipid fractions (lipoprotein (a), LDL), inflammatory markers (high-sensitivity C-reactive protein, homocysteine, interleukins, tumor necrosis factor-α), endothelial functional activity indices (endothelin-1), thrombogenic factors (soluble CD40L), and glycated hemoglobin.. prospective observational study showed the absence of significant positive changes in the lipid profile and the preserved prolonged inflammation response as indicated by interleukin-1β, highsensitivity C-reactive protein, homocysteine, matrix metalloproteinases and the presence of disorders in the endothelin system in both groups of patients. Conclusion: The study showed that long-term endothelial inflammation is the initiating factor of destabilization of the atherosclerotic process is more pronounced in patients with coronary heart disease and diabetes.
Email: Musihina@cardio.tmn.ru
