Habiba S Al Safar
Khalifa University of Science, Technology&Research, United Arab Emirates
Posters-Accepted Abstracts: J Diabetes Metab
Type 2 diabetes (T2D) is one of the most common form of diabetes with various chronic complications. Methylenetetrahydrofolatereductase (MTHFR) polymorphisms are genetic variations that have been linked to T2D and its complications. The objective of this study was to investigate the possible association of MTHFR C677T and A1298C mutations with T2D and evaluate if there is an association with clinical and demographic characteristics among Emiratis population. The genotype and allele frequencies of MTHFR C677T and A1298C polymorphisms showed no significant differences between the patients with T2D and the controls. A significant association was observed between the C677T mutation and history of CVD, history of nephropathy and LDL cholesterol. Also, the A1298C mutation was associated with triglycerides in T2D patients. In conclusion, we did not find a significant association between the MTHFR gene polymorphisms and T2D per se, but there were a significant association between these polymorphisms and T2Drelated complications such as history of CVD,history of nephropathy, LDL cholesterol and triglycerides in the Emiratis population.
Email: habiba.alsafar@kustar.ac.ae
