Amanuel Tadelle
Jimma University southwest, Ethiopia
Posters & Accepted Abstracts: Gen Med (Los Angeles)
Background: Liver disease affects the electrophysiology of the heart. ECG abnormalities, especially QT interval prolongation are common in CLD. Heart rate affects QT interval, so QT interval is reported as corrected QT interval (QTc). The mechanism of QTc interval prolongation in patients with CLD is related to dysfunction of the autonomic nervous system. Objective: To assess QT interval prolongation among patients with chronic liver disease. Methods: The semi-structured questionnaire, ECG machine, automatic serum analyzer, and centrifuge were data collection instruments. Serum HDL, total proteins, albumin, bilirubin, electrolytes, triglycerides, total cholesterol, and fasting glucose were measured during data collection. LDL cholesterol was calculated. Prothrombin time was measured and INR was calculated. The severity of liver diseases was determined by the Child Pugh classification (CTP score), so patients were classified by CTP score (class A, class B, or class C). Result: 27(32.5%) were males and 56(67.5%) were females. 39 (47%) patients were in child class B and 44(53 %) patients were in child class C. But no patients were in child class A. Among all male CLD patients, 14(35.9%) were in child class B and 13(29.5%) were in child class C. Among all female patients, 25(64.1%) were in child class B and 31(70.5%) were in child class C. 52(94.5%) of the patients had QT prolongation, 49(89.1%) of the patients had QTc prolongation. Among QT prolongation, 24(61.5%) was in Child B, 28(63.6%) was in Child C, and among QTc prolongation, 6(15.4%) was in Child B, 43(97.7%) was in Child C. The independent factors significantly associated with QT interval prolongation in this study were systolic hypotension (p=0.003) and overweight (p=0.018). Keywords: CLD, Q-T interval, Child-Pugh Classification Conclusion: QT and QTc prolongation was observed. The prolongation also was increased especially when the disease is more advanced like in child C.
