Faramarz Jalili
Kermanshah University of Medical Sciences, Iran
Posters & Accepted Abstracts: Nat Prod Chem Res
Morphine consumption can decrease fertility drive in males through inducing oxidative stress and DNA damage. Anethum graveolens is a multipurpose herb in traditional medicine for which some anti-oxidative and anti-inflammatory properties have been identified. This study was set to investigate whether the Anethum graveolens could be inhibited morphine adverse effects on reproductive parameters. This experimental study was conducted under approval of Ethics Committee of Kermanshah University of Medical Sciences. In this study fifty six BALB/c male mice with weight range of 25-30 g were purchased from Tehran Razi Institute. The animals were maintained on a 12 h dark/light cycle at about 22 ± 3 oC and allowed free access to standard laboratory diet (Pars Co.) The mice were randomly assigned to 8 groups (n=7). The control group was administered saline (1 ml/kg) and experimental groups were administered morphine (10 ml/kg), Anethum graveolens (150, 300, and 600 mg/kg) and Anethum graveolens (150, 300, and 600 mg/kg) plus morphine (10 ml/kg) interaperitoneally (IP) for 28 consequent days and reproductive parameters were determined. The results indicated that morphine administration (0.5 mg/kg) significantly decreased testosterone level, count and motility of sperms, and testis weight compared to control group (p<0.01). However, increasing the dose of Anethum graveolens significantly increased reproductive indices in most of the groups (p<0.01). Thus, it seems that Anethum graveolens inhibits morphine-induced adverse effects on reproductive parameters.
Email: faramarz_jalili@yahoo.com
