Sara Glessa, Fatma Emaetig, Mussa Alragig, Nabil Elnattah, Kari Syrjänen, Mamduh Jaber, Esraa Samir Obida, Mohamed Elfagieh and Adam Elzagheid
University of Benghazi, Libya
Misurata University, Libya
Misurata Cancer Centre, Libya
Biotechnology Research center, Libya
Biohit Oyj, Finland rretos Cancer Hospital, Brazil
Posters & Accepted Abstracts: Surgery Curr Res
Aim: To assess the prognostic significant of survivin and livin expression in invasive breast cancer and their lymph node metastases. Materials & Methods: The present series consists of archival samples from 78 women with invasive breast cancer diagnosed and treated during 2010â??2014 at Misurata Cancer Center, Misurata, Libya. Tumor biopsies were analyzed for expression of survivin and livin by immunohistochemistry and different grading systems were tested for their expression. Results: In the cancer samples, a significant correlation was established between survivin expression and site of tumor (p=0.021), tumor recurrence (p=0.036), and unifocal tumor (p=0.001), Moreover, HER-2 negative tumors had higher survivin expression than HER-2 positive tumors (p=0.047). There was no association of survivin expression and histological grade, histological type, lymph node status, tumor stage, TNM classification, estrogen, progesterone receptors, distant metastases, chemotherapy, radiotherapy, hormone replacement, vascular invasion, surgical margin, positive family history. Livin expression in the primary breast cancer shows a significant correlation (p=0.025) with positive family history, but no significant association with other clinicopathological parameters. In addition, we found that primary tumors show higher survivin expression (82%) compared with the lymph node metastases (34%), whereas livin expression did not differ between the primary (71%) tumors and their metastases (84%). Conclusion: Survivin expression in the primary breast cancer is significantly associated with several characteristics of favorable prognosis. Livin expression in the primary breast cancer is significantly associated only with a positive family history of breast cancer. f_m_amaitik@yahoo.com
