Serdar Sivgin, Suleyman Baldane, Leylagul Kaynar, Fatih Kurnaz, Cigdem Pala, Muzaffer Keklik, Hayati Demiraslan, Bulent Eser, Ali Unal1and Mustafa Cetin
Posters: Surgery Curr Res
Objectives and aim : Invasive fungal pneumonia (IFP) has become increasingly common in patients that previously underwent alloHSCT due to prolonged neutropenia, immunosuppressive therapies to prevent Graft-vs-host disease (GvHD) and widespread use of broad-spectrum antibiotics. The aim of this study was to determine the role of hyperferritinemia in invasive fungal pneumonia in patients that underwent alloHSCT. Materials and Methods: Medical records of 73 patients with pneumonia that underwent alloHSCT were studied retrospectively, whereby a pre-transplantation serum ferritin level measured up to 100 days prior to transplantation of patients with invasive fungal pneumonia (IFP) and non-fungal pneumonia (non-IFP) was compared. Results: Patient records revealed 35 and 38 cases of IFP and non-IFP respectively. All 35 patients diagnosed with IFP also showed signs of probable pneumonia. Isolated causative microorganisms were Candida spp in five (14.2 %) of the patients and Aspergillosis in three (8.6 %). In risk evaluation for IFP, age, gender, HLA status, conditioning regimen, CD34+ count, donor gender, GVHD presence, smoking history, and underlying disease were not significantly different among groups (p > 0.05). However, performance status (Karnofsky) was significantly lower in patients with IFP (p < 0.05), compared to the control group. The median ferritin levels were 1705 ng/ml (41 − 7198) in the IFP group and 845 ng/ml (18 − 7099) in non-IFP group and the difference was found statistically significant (p = 0.001). Conclusion: Elevated pretransplant serum ferritin level is associated with IFP in patients that underwent alloHSCT, in particular when values exceed 1550 ng/ml. Keywords: alloHSCT, invasive fungal pneumonia, ferritin, aspergillosis, survival.
