Raja chaaba
University of Monastir, Tunisia
Posters & Accepted Abstracts: J Diabetes Metab
Type1 diabetes is one of the major concern for the health care in the world. It is associated with microvascular and macrovascular complications, mainly cardiovascular diseases (CVD). Disturbances in lipid and lipoprotein metabolism play an important role in inducing CVD in the case of diabetes. Many genes implicated in lipid and lipoprotein metabolism are considered as candidate genes for CVD. Lipoprotein lipase (LPL), Lecithin cholesteryl acyl transferase (LCAT), apolipoprotein. (apo E), apo B, apo A-V, cholesteryl ester transfer protein (CETP)â?¦ Many studies of polymorphisms in those genes showed their association with CVD. But those associations are ethnic dependent. They depend on gene-gene or gene environment interactions. Also, the significance of those associations depends on the studied group: the results are different in healthy subjects, diabetic patients, patients with CVD. Then gene-disease association studies in different populations and different groups can help in understanding the disease pathology and also lead to better treatment. It promises to yield information that may be used to personalize treatment strategies to assure optimal lipid control in all patients, improve treatment efficacy and reduce the risk of CVD complications. It help physicians to take the best decision regarding the patient treatment and lay the foundation for "personalized medicine". Genetic testing may not only help to determine who is at high risk for developing CVD, but may also be useful in guiding treatment regimens for T2D.
Email: rchaaba@yahoo.fr
