Zahia Kabouche
Accepted Abstracts: Nat Prod Chem Res
Chrysanthemum herbs (Asteraceae) are extensively used as food additives and in folk medicine. Anti-cancer, anti-human immunodeficiency virus type 1 (HIV-1), anti-inflammatory, antinociceptive and antiproliferative activities as well as antioxidant effects have been reported for Chrysanthemum species. We report the isolation and identification of flavonoids and new and known terpenoids from the endemic species, C. macrocarpum and C. deserticolum ?guertoufa?, used in Algerian Sahara as tea drinks and in ?couscous? and soups ?Chorba?. Structures of the isolated compounds were established by 1-D and 2-D homo and hetero-nuclear NMR (1H, 13C, COSY, HSQC, HMBC, and NOESY), mass spectrometry, UV and comparison with literature data. C. deserticolum extracts were tested by four methods to identify the antioxidant activity namely, ABTS?+, DPPH? scavenging, CUPRAC and ferrous-ions chelating activity methods. The in vitro anticholinesterase activity was achieved by the use of the basic enzymes that occur in causing Alzheimer?s disease: acetylcholinesterase (AChE) and butyrylcholinesterase (BChE). Anti-inflammatory, antinociceptive, antiproliferative and antioxidant activities of C. macrocarpum extracts and isolated compounds are also reported here.
Zahia Kabouche has completed her PhD from the University of Rennes 1, France. She is currently working as a Professor in Department of Chemistry, University of Constantine 1, Constantine, Algeria. She has published more than 100 papers in different scientific journals and is actively serving several scientific journals as a referee and as an editorial board member.
