Anu Kajal
M M University, India
Posters & Accepted Abstracts: J Diabetes Metab
Chronic hyperglycemia leads to the generation of reactive oxygen species leading to oxidative stress. Formation of advanced glycation end products (AGEs) along with oxidative stress leads to cellular damage and development of diabetic nephropathy (DN). The present study was aimed to evaluate alcohol and hydro-alcohol extract of C. cajan seeds in treatment of diabetic nephropathy. Diabetes was induced in male wistar rats by streptozotocin (65 mg/kg i.p.) 15 min after Nicotinamide (230 mg/kg, i.p.) administration. After 30 days of diabetes induction, the rats were treated with different doses of extracts (100, 200 and 400 mg/kg) for 45 days in order to analyze their nephroprotective effect, by means of serum glucose, urea, uric acid, creatinine level and formation of AGEs in kidneys. Tissue antioxidant activity was assessed by measuring level of SOD, CAT, GSH, LPO along with their histopathological examination. Alcohol and hydro-alcohol extracts of C. cajan produced significant attenuation in the serum glucose level, uric acid, creatinine and lipid levels. Moreover there is improvement in the level of SOD, CAT, GSH and decrease lipid peroxidation in terms of TBARS. The formation of AGEs in kidneys was also significantly reduced.These findings suggest that C. cajan might inhibit the progression of DN and could be a therapeutic agent for regulating several pharmacological targets for treatment or prevention of DN.
Email: anukajal523@gmail.com
