Mustafa Aldemir
Kocatepe University, Turkey
Posters-Accepted Abstracts: Surgery Curr Res
Objective: The aim of this study was to evaluate the effects of two widely used adrenoceptor beta-blockers, namely nebivolol and metoprolol on erectile function in males undergoing coronary artery bypass grafting. Methods: Sixty patients scheduled for coronary artery bypass grafting surgery were randomly assigned into two groups: the N group, which received 5 mg of nebivolol orally for 2 weeks before surgery plus 12 weeks after surgery or the M group, which received 50 mg of metoprolol orally for the same period. All patients were evaluated by the erectile function domain of the International Index of Erectile Function-5 (IIEF-5) at time of admission (before starting beta blocker) and three months after surgery. Results: In the metoprolol group, the mean IIEF-5 score decreased significantly from a baseline of 15.2±5.8 to 12.9±5.8 (p<0.001), but in the nebivolol group this difference was not statistically significant (from baseline 12.9±5.5 to 12.4±5.5 and p=0.053). For all patients the mean IIEF-5 score decreased significantly from a baseline of 14.0±5.7 to 12.6±5.6 (p<0.001). Conclusion: While the selective β1-blocker metoprolol significantly affects erectile function, the vasodilating selective β1- blocker nebivolol exerts protective effects on erectile function against the disruptive effects of cardiopulmonary bypass in patients undergoing coronary artery bypass grafting.
