I E Ebhohimen, N P Okolie, G I Eze and L Edemhanria
Samuel Adegboyega University, Nigeria
University of Benin, Nigeria
University of Benin, Nigeria
Posters & Accepted Abstracts: Nat Prod Chem Res
This study evaluated the ability of ethanol extract of Aframomum angustifolium seeds to ameliorate the nephrotoxic effect of potassium bromate (KBrO3) in rats. Biochemical alterations following co-administration of extract with 30 mg/kgbw KBrO3 were monitored in four animal groups (3rats/group). Oral administration lasted for 28 days. Biomarkers were monitored using standard spectrophotometric methods. Kidney SOD and CAT activities, as well as serum HCO3- and creatinine levels were significantly lower (p<0.05) in the treated groups than in the positive control group. Photomicrographs of kidney tissue support the biochemical observations. These findings suggest that the extract mitigated bromate-induced kidney lesions in the treated rats.
Ebhohimen, Israel Ehizuelen is a postgraduate student of the University of Benin, Nigeria and an Assistant Lecturer in the Department of Chemical Sciences (Biochemistry), Samuel Adegboyega University, Ogwa, Edo State, Nigeria. He is a Member of the Institute of Public Analysts of Nigeria and serves as a reviewer in the Tropical Journal of Natural Product Research.
Email:israel.ebhohimen@gmail.com
