Khalid Khalaf Alharbi
King Saud University, KSA
ScientificTracks Abstracts-Workshop: J Diabetes Metab
The ubiquitin-conjugating enzyme E2E 2 (UBE2E2) gene plays an important role in insulin synthe¬sis and secretion under
conditions in which stress to the endoplasmic reticu¬lum is increased in β-cells. In this case-control study, we have selected the
rs7612462 polymorphism within the UBE2E2 gene to identify in Saudi population with type 2 diabetes mellitus (T2DM) subjects.
In total, 376 subjects with T2DM and 380 controls were enrolled in this study. We have collected 5 mL of peripheral blood from
each participant for biochemical and molecular analyses. PCR-RFLP was used to generate genotypes at rs7612462 in all of the study
subjects. Clinical data and anthropometric measurements of the patients were significantly different from those of the controls
(p<0.05). All of the subjects used in this study were non-obese (25 Email: kharbi@ksu.edu.saBiography :
