Awadhesh K. Arya, Deepa Pokharia and Kamlakar Tripathi
Posters: J Diabetes Metab
Diabetes mellitus is a metabolic disorder that also involves the vascular system. It is the most potent risk factor for coronary artery disease (CAD); imposes a great burden on health care worldwide. Many interleukins (IL) play a very important role in the pathogenesis of CAD in which IL-7 is a major regulator of T-cell homeostasis which is concerned in the stimulation of leukocyte-endothelial cell adhesion during infl ammatory events. We hypothesized that circulating IL-7 is associated with activation of monocytes and natural killer cells, leading to enhanced production of infl ammatory cytokines and chemokines observed in atherosclerosis and acute coronary syndromes. Plasma levels of IL- 7, hs-CRP and MCP-1 were measured by an immunoenzymatic ELISA technique. Fift y patients with type 2 DM were divided into two groups: those with higher risk of CAD (n=25) and those without CAD (n=25). Twenty healthy subjects of same age group were included for control. Plasma IL-7 concentration was signifi cantly correlated with plasma MCP-1 concentration and the correlation remained aft er adjustment for age and body mass index (BMI). Plasma IL-7 levels also showed signifi cant positive correlations with plasma levels of hs-CRP. We conclude that there is a relationship between circulating IL-7, MCP- 1 and hs-CRP, and that IL-7 may plays a role in the promotion of clinical instability in coronary artery disease of T2DM by enhancing the expression of MCP-1 in monocytes.
Awadhesh K. Arya has completed his M.Sc. in Biotechnology from University of Calicut and presently pursuing Ph.D from Department of Medicine, Institute of Medical Sciences, BHU, India from January 2007 under the supervision of Dr. Kamlakar Tripathi, who is renowned scientist and physician in the fi eld of diabetes mellitus. He is working to fi nd out various immunological markers which are responsible for the pathogenesis of diabetes and its complications. In this series he has found out very good results which are under the process of publication. He has published four paper and one book chapter in reputed journals.
