Luis Sobrevia
Pontifica Universidad Catolica de Chile, Chile
Posters & Accepted Abstracts: J Diabetes Metab
Gestational diabetes mellitus (GDM) is a disease that occurs during pregnancy and is associated with maternal and fetal hyperglycaemia. Women with GDM are treated via diet to control their glycaemia; however, a proportion of these patients does not achieve the recommended values of glycaemia and are subjected to insulin therapy until delivery. Even if a diettreated GDM pregnancy leads to normal maternal and newbornâ??s glucose levels, fetoplacental vascular dysfunction remains evident. Thus, control of glycaemia via diet does not prevent GDM-associated fetoplacental vascular and metabolic alterations and hence, we presented evidence regarding insulin therapy in the context of its potential consequences for fetoplacental vascular function in GDM. The results suggest that in this insulin therapy, for it to produce normoglycaemia in the mother and newborn may require additional therapeutic measures to restore the normal metabolic condition of the vascular network in GDM. It was also observed that A1, A2A adenosine receptors and insulin receptors A and B has a potential functional link in the cell signaling, which is associated with the activation of these receptors. This possibility could be helpful for the planning of strategies, including adenosine receptor-improved insulin therapy, for the treatment of GDM patients, thereby promoting the well being of the growing fetus, newborn and mother.
Email: sobrevia@icloud.com
