Imad M Taj Eldin
Accepted Abstracts: J Diabetes Metab
Background: Diabetes mellitus is a chronic disease caused by inherited and/or acquired deficiency in production of insulin by the pancreas, or by ineffectiveness of the produced insulin. Objectives: The present study was carried out to investigate the effects of Allium cepa in diabetic rats. Methods: Alloxan-induced diabetic rats? model was conducted to demonstrate the effects of the oral administration of Allium cepa ethanolic extract. Results: Allium cepa showed a moderate time dependent reductions in blood glucose, with a significant decline after 20 days. Furthermore, it?s clinical improvement and/or increased survival rates in alloxan-induced diabetic rats were evident and it was found superior to glibenclamide. Comparative histopathological studies of the pancreas of these animals revealed a remarkable regeneration of beta-cells caused by Allium cepa. Conclusions: Allium cepa extract produced hypoglycemic effects and restorative activity of the pancreas, thus it could be used as a dietary supplement in management of diabetes.
