Rahmani SH, Erfani R and Elmi S
Posters: Surgery Curr Res
Introduction: Fentanyl administration frequently used during the induction of general anesthesia and can reduce hyper dynamic reaction of trachea. Fentanyl-induced cough is not an uncommon condition during the induction of general anesthesia. Various attempts have been made to reduce the incidence of fentanyl-induced cough during anesthesia induction. Propofol may also induce bronchodilation. We hypothesized that an appropriate dose of propofol might suppress fentanyl-induced cough. So, we designed a randomized controlled study to observe the effects of propofol on fentanyl-induced cough during anesthesia induction. Method: A total of 113 patients aged 25 to 60 years, of American Society of Anesthesiologists physical status I/II, scheduled to undergo elective orthopedic surgery with general anesthesia were enrolled in the present study. Patients were randomly allocated to two groups. Group 1 patients were given fentanyl at a dosage of 4 μg/kg; Group 2 patients received 4 μg/kg fentanyl and 20 mg propofol. Two groups were evaluating in 0,5,10 minute after injection. For statistical analysis, we used SPSS Statistics version 17 software. Results: Patients Mean age was 35?10.96, weight 67.99?10.92, and height 161.33?31.84. The incidence of fentanyl induced cough was 29 (51.8%) in placebo group compared with 10 (17.5%) in fentanyl group There was significant difference in the incidence and severity of cough between groups 1 and 2 (p<0.000). Conclusion: A priming dose of more than 20 mg of propofol given 1 minute before fentanyl is effective to suppress fentanyl- induced cough. Key words: fentanyl, cough, propofol
