Estari Mamidala
Accepted Abstracts: J Diabetes Metab
Background: The intestinal digestive enzymes alpha-glucosidase and alpha-amylase are plays a vital role in the carbohydrate digestion. Plant based medicaments are extensively used for the treatment of various ailments of human beings. Objective: The aim of the present study was to investigate the in vitro anti-diabetic activity of the methanolic extract of Physalis angulata fruits. Methods: Plant material was subjected to sequential extraction by maceration method by using different solvents. Antidiabetic activities of Physalis angulata fruit extracts were evaluated using inhibition of alpha amylase and alpha glucosidase enzymes. Results: The assay results suggests that the extract exhibit the dose-dependent increase in inhibitory effect on alpha glucosidase enzyme (upto 82.52%), and alpha-amylase enzyme (upto 94.6%). The current study proves that the antidiabetic activity of extract of Physalis angulata fruits by in vitro studies. Conclusion: From the data obtained in the current studies, it was observed that the fruit extracts of Physalis angulata showed prominent antidiabetic properties by in vitro and further the studies can be need to carried out for isolation of active principle responsible for activity.
