Aya Elmarsafawi
Cairo University, Egypt
Posters & Accepted Abstracts: Surgery Curr Res
Aim: Aim of this study is to compare different perioperative statin regimens for the prevention of post coronary artery bypass grafting (CABG) adverse events. Method: A randomized prospective study was done at cardiothoracic surgical units in a government hospital. 94 patients scheduled for elective, isolated on- or off- pump CABG. Patients were randomly assigned to one of three treatment groups; group I (80 mg atorvastatin/day for two days preoperatively), group II (40 mg atorvastatin/day for five-nine days preoperatively) or group III (80 mg atorvastatin/day for five-nine days preoperatively). The same preoperative doses were restarted postoperatively and continued for one month. Results: Cardiac troponin I (TnI), creatine kinase (CK-MB) and C-reactive protein (CRP) were assayed preoperatively, at 8, 24, 48 hours postoperatively and at discharge. CRP levels at 24 hours (p=0.045) and 48 hours (p=0.009) were significantly lower in group III compared to the two other groups. However, troponin I levels at 8 hours (p=0.011) and 48 hours (p=0.025) after surgery were significantly lower in group II compared to group III. The incidence of postoperative major adverse cardiac and cerebrovascular events (MACCE) was assessed and there was no significant difference among the three groups. Conclusion: The three regimens did not result in any significant difference in outcomes but only simple trends. The higher dose regimen resulted in a significant reduction CRP level. Thus, more studies are needed to confirm the benefit of higher dose statins for the protection from post CABG adverse events.
