Naheed Aryaeian, Arablou T, Sharifi F, Hosseini A, Valizadeh M
Iran University of Medical Sciences, Iran
University of Medical Sciences, Iran
Zanjan University of Medical Sciences, Iran
Iran University of Medical Sciences, Iran
Scientific Tracks Abstracts: J Diabetes Metab
Background and Objective: Diabetes mellitus is a common metabolic disorder characterized by highblood glucose concentrations. The present study assessed the effect of ginger consumption on glycemicstatus, insulin resistance, and inflammatory markers in patients with type 2 diabetes mellitus. Materials and Methods: This was a randomized, double-blind, placebo-controlled clinical trial. The 70type 2 diabetic patients were randomly allocated to an intervention (ginger) group (n=35) or control group(n=35). The intervention group consumed 1600 mg powdered ginger and the control consumed 1600 mg wheat flour placebo (2 capsules of 800 mg) daily for 12 wk. Fasting plasma glucose, hemoglobin A1C,insulin, HOMA index, prostaglandin E2, and TNFα were measured and compared using statistical testsbefore and after intervention. Results: The results of 63 patients were analyzed (intervention group, n = 33; control, n=30). The analysisshowed that the consumption of ginger decreased fasting plasma glucose (p = 0.02), hemoglobin A1C(p=0.01), insulin (p=0.00), HOMA index (p=0.00) and prostaglandin E2 (p=0.00) significantly over the control. Conclusion: The consumption of ginger increased the glycemic status and insulin resistance, anddecreased the inflammatory marker for prostaglandin E2 in type 2 diabetic patients. Keywords: Ginger, Type 2 diabetes, Blood sugar, Insulin resistance, Inflammation 1-Mahluji S, Attari VE, Mobasseri M, Payahoo L,Ostadrahimi A, Golzari SE. Effects of ginger(Zingiber officinale (on plasma glucose level,HbA1c and insulin sensitivity in type 2 diabeticpatients. Int J Food Sci Nutr. 2013;64(6):682-6. 2.Ali BH, Blunden G, Tanira MO, Nemmar A. Somephytochemical, pharmacological and toxicologicalproperties of ginger (Zingiber officinale Roscoe): areview of recent research. Food Chem Toxicol 2008;46(2):409-20. 3. Talaei B, Mozaffari-Khosravi H, Jalali B,Mahammadi SM, ajarzadeh A, Fallahzadeh H.The Effect of Ginger on Blood Glucose, Lipid and Lipoproteins in Patients with Type 2 Diabetes: ADouble-Blind Randomized Clinical ControlledTrial. J Shahid Sadoughi Univ Med Sci 2012;20(3):383-95[in Persian]. 4.Shanmugam KR, Mallikarjuna K, Kesireddy N,Sathyavelu Reddy K. Neuroprotective effect ofginger on anti-oxidant enzymes in streptozotocininduceddiabetic rats. Food Chem Toxicol2011;49(4):893-7. 5.Nammi S, Sreemantula S, Roufogalis BD.Protective effects of ethanolic extract of Zingiberofficinale rhizome on the development of metabolicsyndrome in high-fat diet-fed rats. Basic ClinPharmacolToxicol 2009;104(5):366-73.
