John A Avbunudiogba1, Christian A Alalor, Philip F Builders and Success Odozie
Accepted Abstracts: Nat Prod Chem Res
Background: The leaves of Phyllanthus amarus (family: Euphorbiaceae) is reported to have goodmedicinal values such as antitussive properties. However the extract of the plant is verybitter, this constitutes a challenge in formulating an acceptable oral liquid dosage form.Therefore, the aim of this study is to develop a pleasant tasting liquid preparation of theextract by a taste masking technique as well as evaluate some physicochemical propertiesof the formulation that relate to its stability. Methods: Six formulations (A - F) of the extract were prepared. To obtain the most stable andacceptable taste of the herbal syrup the physicochemical properties such as: Colour, taste, pH, specific gravity, as well as its antioxidant activity were evaluated. Results and discussion: Formulation C which contains ethanol, citric acid, glycerin and syrup BP as the taste masking agents was adjudged to have the most acceptable taste and stability. Generally formulations C showed a pH of 6.61 ? 0.02 and 6.62 ? 0.04, specific gravity of 1.24 ? 0.02 g/ml and 1.28 ? 0.01 g/ml immediately after formulation and after storage for 10 weeks respectively. Conclusion: Formulating P. amarus extract with ethanol, citric acid, glycerin and syrup BPproduced palatable and stable herbal syrup.
John A Avbunudiogba holds Masters of Philosophy degree in Pharmaceutics and Pharmaceutical Technology, 2013 (University of Benin, Nigeria); Doctor of Pharmacy degree (Clinical), 2005, (University of Benin, Nigeria); Master in Business Administration (MBA), 2003 (Delta State University, Abraka, Nigeria) and Bachelor of Pharmacy degree (BPharm), 1995 (University of Benin, Nigeria). Currently, he is a Lecturer with Delta State University, Abraka, Nigeria, Faculty of Pharmacy, Department of Pharmaceutics and Industrial Pharmacy. He is also pursuing academic PhD program in Pharmaceutics and Pharmaceutical Technology at University of Benin, Benin City, Nigeria. He has published more than 15 papers in Pharmaceutics and Phytomedicine in reputed journals.
