Nimisha Jain
Al-Ameen College of Pharmacy, India
Posters-Accepted Abstracts: J Diabetes Metab
Chronotherapeutic systems are designed over the concept of chrono-pharmaceutics in which there is specificity in delivering higher amount of drug in a burst at circadian timings correlated with specific pathological disorder to achieve maximum drug effect. In these systems there is a transient release of certain amount of drug within a short period of time immediately after a predetermined off-release period. Diabetes is one of the diseases where the constant drug levels are not preferred but needs a pulse of therapeutic concentration when the blood sugar levels are high i.e., after the meals or at night. Circadian variations of glucose and insulin in diabetes have been extensively studied and the clinical importance of insulin substitution in diabetes has been well exploited. The chronotherapeutic system can be designed to achieve many pulsatile drug deliveries from a single system at the time when the blood sugar level is high i.e., after breakfast, after lunch and post dinner or late at night. The once a day drug chronotherapeutic drug delivery system can be optimized to deliver the drug at the time of requirement of the body and at the site of its action and absorption in the gastro intestinal tract. The system also has the capability to incorporate single drug or multiple drugs with different mechanisms and site of action to achieve holistic patient friendly treatment for the management of the disease.
Email: nimijain@gmail.com
