Hasina Akhter Chowdhury, Fatema Jebunnesa and Liaquat Ali
Bangladesh University of Health Sciences, Bangladesh
Posters & Accepted Abstracts: J Diabetes Metab
Background: Poor compliance to standard Oral Glucose Torrance Test (OGTT) with 75g more glucose load is well a known problem in conducting screening programs for Gestational Diabetes mellitus (GDM). It has been reported that a 1 hr 50 g glucose challenge test (GCT) is a more acceptable and feasible alternative; however, the cut-off levels of post-challenge serum glucose in GCT have been reported to vary in different populations. Aims: An attempt was made in the present study to define the cut-off levels of serum glucose during GCT, which shows best conformity to the more confirmatory OGTT as per WHO Guidelines. Methods: A total of 224 Bangladeshi women who underwent a GCT were prospectively investigated. GCT was performed between 24 to 28 weeks of gestation. Each subject received a 50 grams oral glucose load without regard to the fasting or fed state, followed by determination of 1 hour venous plasma glucose level. Women demonstrating GCT exceeding 130 mg/dl (>7.2mmol/l) received a 75 grams, 2 hour oral glucose tolerance test to determine whether or not they had GDM. Results: Twenty three (10.3%) women were diagnosed to have GDM. The receiver-operator characteristics curve identified a GCT finding above 174 mg/dl as the cut-off value for detecting GDM, which showed sensitivity, specificity, positive predictive value (PPV) and negative predictive value (NPV) of 35%, 90%, 80% and 68% respectively. Conclusion: Based on PPV and NPV, our data suggest that 1 hour-50 grams GCT is a feasible and acceptable screening test and a cut-off value of 174 mg/dl, as the post-challenge serum glucose, may be appropriate for screening GDM in Bangladeshi population by this test.
Email: hachowdhury01@gmail.com
