DaYoung Kim, Nguyen Quoc Tuan, Sung-Tai Han, Gil-saeng Jeong and MinKyun Na
Chungnam National University, Republic of Korea
Korea Ginseng Corporation Research Institute, Republic of Korea
Keimyung University, Republic of Korea
Posters & Accepted Abstracts: Nat Prod Chem Res
The plant M. charantia L., called ??bitter melon? is widely cultivated in Asian countries. It is commonly used as a vegetable and medicine. The extract of the fruit of this plant was shown to posses anti-helmintic, antibacterial, antifertility, antidiabetic, as well as antiproliferative activities. The aim of this study was to identify the unreported six new cucurbitane-type triterpenoids from the fruits of M. charantia, utilizing diverse chromatographic and spectroscopic techniques. In particular, the 2D structure of 1 was confirmed utilizing the long-range HSQMBC NMR pulse, capable of measuring heteronuclear longrange correlations (4-6JCH). The cucurbitanes were also assessed for their inhibitory activity against Platelet-derived growth factor (PDGF)-induced Vascular smooth muscle cells (VSMC) proliferation. In particular, 2 and 4 at 10 μM curbed the VSMC proliferation by 72.4% and 67.9%, respectively, demonstrating significant inhibitory activity among the tested phytochemicals. This study may constitute a basis for developing those chemotypes into sensible pharmacophores alleviating cardiovascular disorders.
DaYoung Kim is a Graduate from the Department of Chemistry at Mokwon University, South Korea. She works at the Pharmacognosy Laboratory of the Colloge of Pharmacy, Chungnam National University, South Korea. She has recently published a paper in Korean Journal of Aesthetics and Cosmetology.
Email:ekdud6980@naver.com
