Anoosha Jonnalagadda and Prem Kumar N
Posters: J Diabetes Metab
Diabetes has been reported to increase propensity to peptic ulceration through its effect both on offensive and defensive mucosal factors. Seeds of Syzygium cumini have been reported to have both anti-diabetic as well as ulcer protective effects. The study evaluated the anti-diabetic effects of ethanolic extract of dried seed kernel of Syzygium cumini (200mg/kg) and its comparative effect on gastric ulceration with standards Acarbose (5mg/kg) an α- glucosidase inhibitor and natural standard Quercetin 50mg/kg&100 mg/kg. The study also investigated the combined effect of Syzygium cumini seed kernel extracts with oral hypoglycemic agents in diabetes induced ulcer. The development of diabetic ulcers was assessed biochemically and histologically. Diabetes was induced by high fat diet/low dose streptozotocin (35mg/kg). Single and repeated dose study was performed in normal and diabetic rats. Syzygium cumini and its combination with standard showed significance in reducing the elevations of gastric ulcer index which is also confirmed by restoration of the depleted antioxidant defenses (superoxide dismutase, catalase and total proteins activities) caused by persistent hyperglycemia. It was concluded that Syzygium cumini along with Acarbose (low dose) represents a potential therapeutic option to reduce the increase in susceptibility to ulcer formation in type 2 diabetic patients.
J. Anoosha, research scholar has completed her B.Pharmacy from Priyadarshini College of Pharmacy, Karnataka, pursuing her Master?s from Rajiv Gandhi University of health sciences. She had attended many workshops and participated in many Conferences like IPC.
