Tshikuka Jose Gaby, Rankgoane-Pono Goabaone, Masupe Tiny, Molefi Mooketsi, Tlhakanelo Thato John, Hamda Shimeles, Vincent Setlhare, Mgaywa Gilbert Mjungu Damas Magafu and Nsikungu-Kalukul Maurice
University of Botswana, Botswana
University of Washington, USA
University of Kinshasa, Republic of Congo
Posters & Accepted Abstracts: J Diabetes Metab
Background: Botswana has been administering free combination antiretroviral therapy (cART) for more than 15 years. cART is not without side effects. Diabetes-related comorbidities (DRCs) are a major group of cART untoward effects worldwide. cART regimens that are highly associated with DRCs and the extent by which they prolong the life of recipients in Botswana are unknown. In addition, biomedical and demographic predictors for DRCs among cART recipients in Botswana are still not well understood. Objective: To investigate the association between cART and DRCs among cART recipients at two HIV clinics in Gaborone, identify underlying biomedical and demographic risk factors for DRCs and investigate survival of patients from initiation on different cART regimens to the development of DRCs. Method: Data from two major HIV clinics in Botswana were reviewed. Associations between different cART regimens and DRCs were investigated among 531 recipients. Recipientsâ?? DRC risk factors were identified. Cox regression model was run. Unadjusted and adjusted hazard ratios were computed and hazard and survival functions for different cART regimens were plotted. Result: HIV patients on second and third-line cART were less likely to develop DRCs than those on first-line cART. Patients with CD4 count â?¤200 cells/mm3 before cART initiation were more likely to develop DRCs than those who had CD4 count>200 cells/mm3. Overweight patients at cART initiation had a higher risk of developing DRCs compared with those who had normal body mass index (BMI). Males had a lower risk of DRCs than females and recipients younger than 35 years had a lower risk of DRCs than those aged 35 years or older. The shortest survival was among patients on the first-line cART whereas the longest survival was among patients on the second-line or third-line cART regimen.
Tshikuka Jose Gaby is currently the Acting Head of Public Health Medicine Unit at the Faculty of Medicine, University of Botswana. He is also an Associate Professor of Epidemiology and Nutritional Epidemiology at the National Pedagogic University of DRC. He has received his PhD in Epidemiology of Infectious Diseases (with concentration in Epidemiology, Parasitology, Biostatistics and Nutrition) from McGill University, Canada. He has extensive experience working with international health organizations including WHO, UNICEF, American Rescue Committee, American Refugee Committee, Health Action in Crisis/WHO, PSI and Action against Hunger. He has worked/conducted research in various parts of the world. He has published 52 publications: 28 journal articles, 12 published conference proceedings and 12 consultancy reports.
Email:Josegaby.tshikuka@mopipi.ub.bw
