Journal of Diabetes & Metabolism

ISSN - 2155-6156

Bone turn over markers in gestational diabetes mellitus: A pilot study

12th European Diabetes Congress

September 15-17, 2016 Berlin, Germany

Abhijit Borse, Saba Noor, Anjum Parwez and Shaheen

Aligarh Muslim University, India

Posters & Accepted Abstracts: J Diabetes Metab

Abstract :

Gestational diabetes mellitus (GDM), defined as impaired glucose intolerance with commencement or recognition during pregnancy affects ~14% of pregnancies. GDM affects maternal, fetal and neonatal well being and is allied with elevated threat of cesarean section and the later advancement to Type 2 diabetes. Hyperglycemic aura in GDM may affect bone via alteration in bone structure, bone density, and markers of bone turnover. The study focused on evaluating the associations of four bone turnover markers (25-hydroxyvitamin D, parathyroid hormone alkaline phosphates and serum calcium) with GDM subjects in a population-based pilot study. Fifty subjects with normal pregnancy and fifty with gestational diabetes mellitus were clinically scrutinized for detailed history and physical examination. Among bone turn over markers parathyroid hormone was significantly raised in GDM patients when compared with normal pregnant females (p=<0.001), whereas 25(OH) D was significantly reduced in GDM subjects. There was no observable significant disparity in ionized calcium between the two groups whereas alkaline phosphates was significantly raised in GDM females (p=0.0038). Linear regression evaluated a significant negative co-relation between PTH and 25(OH) D concentration in hyperglycemic pregnant subjects (r=-0.9037, p=<0.05). Our study shows high prevalence of obesity, hypovitaminosis D and hyperparathyroidism, in females with GDM, in comparison to females without GDM. Pregnancy is a high-bone-turnover state due to increased fetus demands, putting strain on adapting maternal skeleton. Our study concludes that subjects with low 25(OH) D levels can have secondary hyperparathyroidism which can increase insulin resistance and leads to hyperglycemic state. Identifying markers of bone turnover offer a noninvasive and clinically relevant method of monitoring changes in bone during pregnancy and highlight the need of estimation in early pregnancies.

Biography :

Email: drabhijitborse@gmail.com

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