Xiao Xiao, Wei Bao, Wenze Zhong, Di Wang, Shuang Rong, Wei Yang, Yanting Zhao and Liegang Liu
Posters: J Diabetes Metab
Many previous studies that examined the association between vitamin D receptor (VDR) gene polymorphisms and type 2 diabetes mellitus (T2DM) produced confl icting results. Th is systematic review and meta-analysis is conducted to evaluate previous studies and summarize the eff ects of VDR gene variation with risk of T2DM. We searched PubMed/Medline, EMBASE, Cochrane, and CBMweb/CBMdisc for relevant published literatures up to September 7, 2011. Two investigators checked these articles and extracted data independently. Th e odds ratios (ORs) and 95% confi dence intervals (CIs) were pooled by using a random- or fi xed- eff ect model.16 case-control studies enrolling 1899 T2DM patients and 3163 controls met the selection criteria, including 4, 10, 8, 9 and 1 studies eligible for single nucleotide polymorphisms (SNPs) FokI, BsmI, ApaI, TaqI and Tru9I, respectively. Th e pooled ORs and 95% CIs indicated no statistically signifi cant association. Th e summary OR for T2DM among individuals with risk allele vs protective allele was 1.064 (95% CI: 0.947, 1.196). For BsmI, pooled OR was 1.021 (95% CI: 0.732, 1.424); for ApaI, pooled OR was 1.067 (95% CI: 0.957, 1.190); for TaqI, pooled OR was 1.040 (95% CI: 0.878, 1.233). No publication bias was observed. For FokI, pooled OR was 1.258 (95% CI: 1.066, 1.485), however, publication bias existed (p < 0.05), the pooled OR aft er trim-fi ll adjustment was 0.88 (95% CI: 0.68, 1.15). Sensitivity analyses further strengthened the validity of these associations. In conclusion, no suffi cient evidence was found to support an association between the VDR gene polymorphisms and risk of T2DM.
Xiao Xiao has completed her B.S. of medicine at the age of 22 years from Tongji Medical College, Huazhong University of Science and Technology, China, and now is studying for her master?s degress of medicine, major in Nutrition and Chronic medicine. She has participated in three National Nature Science Foundation of China (NSFC), these research projects are all related to type 2 diabetes mellitus.
