Jain G C, Khajja B S and John P J
University of Rajasthan, India
Posters-Accepted Abstracts: J Diabetes Metab
The present study was undertaken to assess anti-diabetic potential of 50% ethanolic extract of Moringa oleifera Lam (Family- Moringaceae) in alloxan induced diabetic rats. Oral administration of acute and sub-chronic doses (100, 200 and 400mg/kg bwt) of Moringa oleifera extract showed a significant reduction in fasting blood glucose level in diabetic rats, however there was no significant effect on the blood glucose level in normal rats. In acute study, the maximum blood glucose reduction (42.04%, 48.19% and 55.31%) was observed at 6 hours after administration of Moringa oleifera extract at 100, 200 and 400 mg/kg b.wt. respectively. Sub-chronic treatment of extract (100, 200 and 400 mg/kg b.wt./day) in diabetic rats showed significant decline in fasting blood glucose level after 7 days and this decline was continued over the period of study (30 days). The maximum fall of blood glucose on day 30 was 46.02%, 53.29% and 58.53% respectively for low, medium and high dose of the extract in comparison to the fasting blood glucose level on zero day. The OGTT, body weight and histopathological study of the pancreas also supported the anti-hyperglycemic action of the extract. The result of the present study strongly supports the anti-diabetic effect of the 50% ethanolic extract of Moringa oleifera leaves.
Email: jain_gc@yahoo.co.in
