Eddouks M, Farid O, Hebi M, Ajebli M, Benaji B and EL Bouhali B
Moulay Ismail University, Morocco
Faculty of Letters and Science Humaines, Morocco
Posters & Accepted Abstracts: J Diabetes Metab
The effect of an aerial part aqueous extract (APAE) of Ruta montana (L.) (RM) at a dose of 5 mg/kg on blood glucose levels was investigated in normal and streptozotocin (STZ) diabetic rats. In this study, histopathological changes were also evaluated in liver and pancreas both in normal and STZ rats. Additionally, the effect of this aqueous extract on glucose tolerance in normal rats was demonstrated. Furthermore, the relative organs weight (R.O.W) of liver, kidney, pancreas and brown adipose tissue were evaluated after 15 days of daily oral administration of the aqueous extract. Both a single and repeated oral of the APAE aqueous extract (5 mg/ kg) produced a significant decrease on blood glucose levels in normal and STZ rats. According to the oral glucose tolerance test, the aqueous extract of RM APAE (5 mg/kg) was shown able to improve the increase on blood glucose levels in normal treated rats 30th min (p<0.01) and 90th min (p<0.001) after administration of 3 g/kg of glucose. We conclude that RM aqueous extract exhibits a potent hypoglycemic effect in normal rats and anti-diabetic effect in STZ rats. This finding supports the use of this plant in the traditional Moroccan use for diabetes management.
Email: mohamed.eddouks@laposte.net
