Irina V. Smirnova, Lisa D. Van Hoose, Rajprasad Loganathan, Lesya Novikova, Lisa Stehno- Bittel, James L. Vacek, Purvi M. Patel, Muhammed and D. Al- Jarrah
Scientific Tracks Abstracts: J Diabetes Metab
Diabetic heart disease involves diastolic and systolic dysfunction. Aerobic exercise attenuates the cardiac dysfunction in diabetes. We aimed to characterize left ventricular hemodynamics in the Zucker Diabetic Fatty (ZDF) rat, a model of type 2 diabetes with complications seen in humans, and evaluate changes induced by exercise training. Male ZDF and Zucker lean (control) rats were assigned to 4 groups: sedentary (SD) and exercised (ED) diabetic, and sedentary (SC) and exercised (EC) control. Exercise training consisted of 8 weeks of running on a treadmill. Hemodynamic changes were determined using left ventricular catheterization and pressure volume analysis. Of the 24 hemodynamic parameters tested, 15 were negatively aff ected by diabetes. Th e debility of diabetic heart disease was evident in the diastolic fi lling, isovolumic contraction, ejection, and isovolumic relaxation phases. Specifi cally, ventricular fi lling was impaired in SD rats with a 23% loss in end diastolic volume. dP/dtmax, an indicator of contractility, showed a 40% reduction while the ejection fraction was 8% lower in SD rats. In addition to compromised ventricular contraction, impaired relaxation was present in SD rats with dP/dtmin levels at 59% of those in controls. Importantly, exercise training restored 13 of the 15 hemodynamic parameters aff ected by diabetes. We concluded that diastolic and systolic dysfunction was present in the ZDF rat model and exercise had a defi nite cardioprotective eff ect on left ventricular hemodynamics in the diabetic rats.
Irina V. Smirnova has earned her PhD degree in protein chemistry from the Institute of Bioorganic Chemistry of the Ukrainian Academy of Sciences in Kyiv, Ukraine. She is a principal investigator in the Diabetes Research Laboratory at the University of Kansas Medical Center. Her research interests include diabetic heart disease and benefi ts of exercise. She has published over 40 papers in peerreviewed scientifi c journals.
