Niraula A, Kunwar S, Thapa S, Lamsal M and Baral N
B P Koirala Institute of Health Sciences, Nepal
Posters-Accepted Abstracts: J Diabetes Metab
Background: Diabetes mellitus is a group of metabolic disorders of carbohydrate metabolism in which glucose is underused, producing hyperglycemia. It is a major worldwide health problem leading to increased mortality and serious morbidity. Adenosine deaminase (ADA) is a polymorphic enzyme that catalyses the irreversible deamination of adenosine to inosine. ADA is considered as a good marker of the cell mediated immunity and it has been an established screening test for tuberculosis. Literature suggests that the serum ADA activity is significantly raised in patients with type 2 DM. Diabetic patients are prone to opportunistic infection, thus serum ADA levels in these patients is very important as a screening test for tuberculosis and autoimmune diseases. Objective: To correlate the serum ADA level with HbA1c, fasting and postprandial blood glucose level in patients with diabetes mellitus. Material & Methods: This is a hospital based cross-sectional study done in B. P. Koirala Institute of Health Sciences. 150 diagnosed patients (72 males and 78 females) with DM were enrolled in the study from April 2014 to August 2014. Fasting, postprandial and HbA1c blood sample was analysed in cobas c311. Serum ADA was done by Giusti method. Data were analysed using SPSS version 20, p value<0.05 was considered significant. Results: Mean age group in the study was 56±11.95. Mean value of HbA1c, fasting and postprandial blood glucose and serum ADA level was 6.54±2.49; 153.45±94.40, 239.56±139.38 and 41.30±19.99 respectively. Serum ADA level was significantly correlated with HbA1c levels (r=0.426, p=0.0001), fasting blood glucose (r=0.297, p=0.0001) and postprandial blood glucose (r=0.278, p value=0.001). Conclusion: There is a significant increase in serum ADA activity in DM with increase in HbA1c levels which may play an important role in predicting the glycemic status in these patients.
Email: apekshyaniraula@gmail.com
