Oren Tirosh
Accepted Abstracts: J Diabetes Metab
This study was designed to elucidate the role of induciable nitric oxide synthase (iNOS) in septic fatty livers with the accentuation on glucose metabolism. Herein, wild type (WT) and iNOS-knockout (iNOS-/-) mice were fed with a high cholesterol diet (HCD, 1%w/w) for 6 weeks. Following diet period, mice were injected with LPS (5 mg/Kg). Chronic consumption of HCD led to non alcoholic steatohepatitis (NASH) in WT and iNOS-/- mice.
