Journal of Diabetes & Metabolism

Neuroprotective and Antioxidative Potentials of Aqueous Crude Extract of Sterculia Tragacantha Leaf in Streptozotocin-Induced Diabetes in Rats

Olusola Augustine O¹ and Onikanni Sunday Amos^{1,2,3* *}Correspondence: Onikanni Sunday Amos, Faculty of Science, Department of Biochemistry, Adekunle Ajasin University, Akungba-Akoko, Ondo-State, Nigeria, Tel: + 2348118138703, Email:

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Present study, as shown in Figure 5a, revealed that AESTL ameliorates the damage done in all treated group when compared with untreated group. This finding is in agreement with previous study in association with an increase in thiobarbituric acid reactive substances (TBARS) in the tissue. Alteration in any antioxidative defense system induces lipid peroxidation and oxidative stress. Enzymes such as SOD, catalase, glutathione peroxidase, glutathione-s-transferase as well as glutathione form the defense system, which usually protects the cell against oxidative damage. In this research study, most of the oxidative stress markers were significantly decreased in streptozotocin-induced rats as shown in Figures 5b, 6 and 7. This is attributable to the medicinal values in AESTL treatment. It has been established that CAT, SOD and GPx play important roles as protective enzymes against free radical formation in tissues. The present studies validate protective roles of the extract (AESTL) in reducing peroxidation level and restore the damaged levels of antioxidant enzymes system.

Conclusion

It can be concluded from this study that AESTL showed great potentials in ameliorating the diabetic conditions, thereby play a protective role on the brain against diabetogenic-oxidative stress causing change in the levels of peroxidation thereby decreasing activities of oxidative markers. Therefore, in reducing diabetesassociated oxidative stress; AESTL could be very helpful in diabetes mellitus management.

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