Junior Resident, Aligarh Muslim University Institute of Ophthalmology, J.N. Medical College and Hospital, Aligarh Muslim University, Aligarh, UP 202002, India
Review Article
Epigenetic Insights: DNA Methylation and Gene Expression in Diabetic Retinopathy?A Mini Review
Author(s): Shaista, Abdul Waris*, Sheelu Shafiq Siddiqi, Tanusree Debbarman, Vivek Ram K.U. and Dimple Thacker
Background: Diabetic Retinopathy (DR) ranks among the primary
causes of vision loss in both developing and developed nations. Its
development, pathophysiology, and prognosis have been linked to
genetics, epigenetics, and environmental factors. Epigenetics have
been linked to normal physiological foetal development during
embryogenesis, cancer, psychiatric disorders, cardiovascular diseases,
renovascular diseases, cerebrovascular diseases, etc. Diabetes, being
one of the diseases that cause multisystem disorders, retinopathy
being one of them, has been closely associated with epigenetics,
especially DNA methylation in its development.
Overview and methodology: Our review article focuses on
the existing literature on epigenetics, mainly methylation. It
discusses the current understanding of global DNA methylation.. View More»
DOI:
10.35248/2155-6156.24.15(11).1178
