Developmental Toxicology Division, Industrial Toxicology Research Centre, India
Opinion
Modified Platelet Capabilities in Non-Insulin-Subordinate Diabetes Mellitus
Author(s): Sanjay Srivasta*
Non-insulin-dependent diabetes mellitus (NIDDM) is a prevalent metabolic disorder associated with diverse cardiovascular complications. Platelets, pivotal players in hemostasis and thrombosis, undergo functional modifications in the diabetic milieu, potentially contributing to the increased risk of vascular events. This study delves into the nuanced alterations in platelet capabilities in NIDDM, aiming to decipher the underlying mechanisms and implications for vascular health. Utilizing a comprehensive array of platelet function assays, including aggregation studies, flow cytometry, and thromboxane A2 release assessments, our investigation reveals substantial modifications in platelet reactivity and responsiveness in individuals with NIDDM. The findings highlight not only hyperreactivity but also nuanced changes in platelet signaling pathways, shedding light on the intricate interplay.. View More»
DOI:
10.35248/2155-6156.10001050
