Department of Endocrinology, Nightingale Hospital, Kolkata, India
Review Article
Define-HF & Emperial Trials: Lessons Learned
Author(s): Samit Ghosal*
Sodium Glucose co-transporter inhibitors (SGLT-2i) have firmly established their position in the management of type 2 diabetes mellitus (T2DM) and have also expanded their indication for use. There were different outcomes benefits with the three SGLT-2i, resulting from differences in patient population studied, primary end-points chosen and statistical testing hierarchy. Although the outcome benefits complemented each other, the subtle differences were blown out of proportion by interested lobbies, eyeing a larger pie of the market share. The corporate war intensified with the publication and top-line results of 2 two recent symptom-based trials in patients with heart failure (DEFINEHF & EMPERIAL). Once again, the differences were subtle and there were more similarities than differences. Diuretics provide the desired symptom relief whereas SGLT-2i are associated with hard end-poin.. View More»
DOI:
10.35248/2155-6156.20.11.848
