Faculty of Pharmacy and Bioanalysis, Research Institute, University of Los Andes, Mérida P.C. 5101, Venezuela
Review Article
Natural and Synthetic Derivatives of the Steroidal Glycoalkaloids of Solanum Genus and Biological Activity
Author(s): Morillo M, Rojas J, Lequart V, Lamarti A and Martin P*
Steroidal alkaloids are secondary metabolites mainly isolated from species of Solanaceae and Liliaceae families that occurs mostly as glycoalkaloids. α-chaconine, α-solanine, solamargine and solasonine are among the steroidal glycoalkaloids commonly isolated from Solanum species. A number of investigations have demonstrated that steroidal glycoalkaloids exhibit a variety of biological and pharmacological activities such as antitumor, teratogenic, antifungal, antiviral, among others. However, these are toxic to many organisms and are generally considered to be defensive allelochemicals. To date, over 200 alkaloids have been isolated from many Solanum species, all of these possess the C27 cholestane skeleton and have been divided into five structural types; solanidine, spirosolanes, solacongestidine, solanocapsine, and jurbidine. In this r.. View More»
DOI:
10.35248/2329-6836.20.8.371
