Department of Biotechnology and Bioinformatics, North-Eastern Hill University, Shillong, India
Commentary
Role of Androgen: Overview
Author(s): Reeman Neonpough*
Androgens are C-19 steroid hormones produced predominantly by the testis and adrenal cortex [1].Androgens, the most prominent male sex steroids, are essential for the formation of the male phenotype throughout embryogenesis and the attainment of sexual maturity at puberty. Androgens are still required for the maintenance of male reproductive function and behavior throughout maturity. Androgens impact a wide range of nonreproductive tissues, including skin, bone, muscle, and the brain, in addition to its effect on reproduction [2]. The androgen receptor, a member of the vast superfamily of ligand-activated nuclear hormone receptors, is where androgens, primarily Testosterone (T) and 5-Dihydrotestosterone (DHT), exert the majority of their actions [3]. Androgens have two natural ligands: testosterone and its more potent metabolite, 5-dihydrotestosterone, both of which bind to AR and tri.. View More»
