SVKM’s Dr Bhanuben Nanavati College of Pharmacy, Vile Parle (W), Mumbai 400056, India
Review Article
HDAC Inhibition Modifies Cardiac PPARs and Fatty Acid Metabolism in Diabetic Cardiomyopathy.
Author(s): Manisha Oza*
Peroxisome proliferator-activated receptors (PPARs) control the
homeostasis of lipids and glucose in the heart. Inhibitors of the enzyme
histone deacetylase (HDAC) have anti-inflammatory properties that
may be crucial in controlling PPARs and fatty acid metabolism. This
study sought to determine whether the HDAC inhibitor MPT0E014 could
influence myocardial PPARs, inflammation, and fatty acid metabolism in
DM cardiomyopathy. In order to assess the electrophysiological activity,
heart structure, fatty acid metabolism, inflammation, and PPAR isoform
expressions in control and streptozotocin-nicotinamide-induced DM rats
with or without MPT0E014, electrocardiography, echocardiography, and
western blotting were used. DM and MPT0E014-treated DM rats showed
decreased body weights and higher blood glucose levels compared to
control rats. DM rats had larger .. View More»
DOI:
10.35248/2155-6156.1000959
