India
Review Article
An update on Etiopathogenesis of Diabetic Kidney Disease and their Therapeutic Implications- A Systematic Review
Author(s): Kulvinder Kochar Kaur*
As we all know Diabetic Kidney Disease (DKD) represents the commonest etiology for Chronic Kidney Disease (CKD) along with end-stage renal Disease (ESRD). Earlier we have reviewed in detail the role of epigenetic modifications in the case of DKD and the medications undergoing trial regarding that like Apabetalone, Apelin, curcumin analogs, sodium, butyrate, the role of bromodomain extra terminal (BET) Proteins, roles of different histone acetylases like KDM6A (alias UTX), enhancer of Zeme Homolog 2 (EZH2) methylases, besides how to avoid propagation of CKD in general. As far as the natural history of DKD goes it is inclusive of glomerular hyperfiltration, propagative albuminuria along with reducing glomerular filtration rate (GFR), and finally renal failure.
We already possess the information that DKD is correlated with metabolic alterations that occur secondary to hyperglycemi.. View More»
