Juvenile Diabetes Research Foundation, New York, USA
Review Article
Two-age islet-autoantibody evaluation for adolescents with type 1 diabetes
Author(s): Jessica Dunne*
Type 1 diabetes (T1D) is an autoimmune condition characterized by the destruction of insulin-producing pancreatic beta cells. Detecting islet autoantibodies in children at risk for T1D is crucial for early intervention and timely management. This study proposes a novel two-stage islet autoantibody evaluation approach to enhance the accuracy of T1D prediction in childhood.
A cohort of 500 children, aged 2-12 years, with a familial history of T1D or genetic predisposition, were enrolled in this prospective study. In the first stage, samples were screened for the presence of glutamic acid decarboxylase (GAD) and insulinoma-associated-2 (IA-2) autoantibodies using highly sensitive and specific assays. Participants with positive results proceeded to the second stage, where zinc transporter 8 (ZnT8) and islet cell autoantibodies (ICA) were further assessed. Follow-up evaluations w.. View More»
DOI:
10.35248/2155-6156.10001044
