Centre for Advanced Drug Research, COMSATS Institute of Information Technology, Abbottabad-22060, Pakistan
Research Article
Vitellaroside, A New Cerebroside from Vitellaria paradoxa (Sapotaceae) and its Bioactivities
Author(s): Jean Noël Nyemb*, Alembert T Tchinda, Emmanuel Talla, Emmanuel B Nanga, David T Ngoudjou, Céline Henoumont, Sophie Laurent, Jamshed Iqbal and Joseph T Mbafor
A new cerebroside (2R)-2-hydroxy-N-[(Z,2S,3S,4R)-1-O-β-D-glucopyranosyl-3,4-dihydroxynonadec-8-en-2-yl] nonacosanamide (1) was isolated from the wood of roots of V. paradoxa along with six known compounds including catechin (2), quercetin (3), spinasterol 3-O-β-D -glucopyranoside (6), gallic acid (7) and a mixture of β-sitosterol (4) and stigmasterol (5). The structure of the new compound was established by 1D (1H and 13C NMR) and 2D NMR (COSY and HSQC) spectroscopy, extensive mass spectrometry and by comparison with published data. The antibacterial, α-glucosidase and alkaline phosphatase (AP) inhibitory activities of all the pure compounds were evaluated. The antibacterial activities were evaluated against three gram negative bacteria (Escherichia coli; Salmonella typhimurium and Pseudomonas aeruginosa) while APs inhibitory activities were eval.. View More»
DOI:
10.4172/2475-7675.1000306
