Department of Forensic Pathology, Stellenbosch University, Stellenbosch, South Africa
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Advanced Genotyping of DNA Fingerprints Using a Model Created From Actual Chip Electrophoresis Data
Author(s): Hyejung Weinmann*
Due to the superior precision of the digitalization process, extensive
comparative studies of DNA fingerprints favour automated chip
capillary electrophoresis over traditional gel planar electrophoresis.
The device resolution and sizing accuracy, however, continue to be
a constraint on band size determination. Therefore, band matching
continues to be the most important stage in DNA fingerprint
analysis. The capacity to discriminate between closely related
samples is regrettably greatly diminished by the majority of current
approaches, which merely assess the pairwise similarity of the
samples and use heuristically computed constant thresholds to
assess the maximum permissible band size divergence. This work
introduces a novel method based on global multiple band
alignments of all samples, with an adaptive threshold obtained from
the in-depth migr.. View More»
DOI:
10.35248/2684-1312.23.8(1).354
